Christina Applegate says she was misdiagnosed with MS

Christina Applegate reveals multiple sclerosis diagnosis
Matt Winkelmeyer/Getty Images
October 20, 2026, 8:26 AM

Actress Christina Applegate says she was misdiagnosed with multiple sclerosis (MS), a neurological and autoimmune disorder.

"It's hard to say that [my doctor] came into my room and she said, 'Congratulations! You don't have MS,'" Applegate said on Tuesday's episode of MeSsY, her podcast with co-host Jamie Lynn Sigler.

Applegate first revealed on social media in 2021 that she was diagnosed with MS.

This is a developing story. Please check back for updates.

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