COVID-19 updates: American Airlines to require employee vaccinations

Approximately 118 million Americans remain completely unvaccinated, including 70 million over the age of 12, according to federal data.

On Wednesday, the U.S. is likely to reach a significant vaccine milestone of 200 million adults vaccinated with at least one dose.

Alaska currently has the country's highest infection rate with daily cases up by nearly 2,500% since mid-July, according to federal data.

West Virginia, once a model for its vaccine rollout, now has more hospitalized patients than at any point in the pandemic. 

But states including Florida, Mississippi, Louisiana and Georgia appear to be improving, federal data show.

Nationwide, around 79,000 people are hospitalized, down by more than 20% since the beginning of September. Even so, ICU capacities in several states, including Alabama, Georgia, Idaho, Kentucky and Texas, remain at critical levels.

-ABC News' Arielle Mitropoulos

United Airlines plans to immediately terminate up to 593 employees who chose not to get vaccinated under the airline’s mandate.

United said more than 99% of its employees chose to get vaccinated.

Roughly 2,000 employees sought a medical or religious exemption. Because of ongoing litigation, United said it will not reveal how many employees were granted exemptions. United says anyone who applied for an exemption will still be allowed to go to work until a final decision is made on how to handle their cases. The airline expects a decision by Oct. 15.

-ABC News' Sam Sweeney

The Food and Drug Administration's approval for the Pfizer vaccine for children between 5 and 11 years old could begin in November, possibly before Thanksgiving, a federal official with knowledge of the agency's process told ABC News.

This prediction comes after Dr. Anthony Fauci said Tuesday kids will likely start getting vaccinated by late October.

Another official told ABC News that Pfizer has yet to complete its full submission, and that the FDA is not going to be rushed on this.

Pfizer submitted it initial data on younger children to the FDA earlier Tuesday.

The FDA already has scientists reviewing that initial data submitted by Pfizer, according to the official.

-ABC News' Anne Flaherty and Eric Strauss

The COVID-19 Forecast Hub's ensemble forecast, used by the CDC, predicts that U.S. hospitalizations will continue to fall -- perhaps to as low as 4,600 per day -- by Oct. 11.

Forecasters say around 1,600 fewer people are likely to die over the next two weeks than during the past two weeks. In the two weeks ending Sept. 25, at least 27,755 people died from COVID-19 in the U.S. Over the next two weeks ending Oct. 19, just over 26,000 deaths are expected.

-ABC News' Brian Hartman