As Iran retaliates, largest US military base in Middle East hit by ballistic missile, Qatar says

The U.S. and partners began the joint attack on Iran at 1:15 am ET to "dismantle the Iranian regime’s security apparatus, prioritizing locations that posed an imminent threat," U.S. Central Command (CENTCOM) said in its first statement since the attacks on Iran began.

The attack targets include "Islamic Revolutionary Guard Corps command and control facilities, Iranian air defense capabilities, missile and drone launch sites, and military airfields," CENTCOM said in its statement.

“The President ordered bold action, and our brave Soldiers, Sailors, Airmen, Marines, Guardians, and Coast Guardsmen are answering the call,” CENTCOM Commander Admiral Brad Cooper said in the statement.

"There have been no reports of American fatalities or combat-related injuries," and "damage to U.S. installations was minimal and has not impacted operations," according to CENTCOM.

Residents near an industrial complex in Isfahan, Iran, are being warned about an attack on military infrastructure "in a few minutes," the Israel Defense Forces warned in a post on X Saturday.

Residents are being told to evacuate the area "immediately."

Iranian President Masoud Pezeshkian and Supreme Leader Ayatollah Ali Khamenei are "safe and sound," Foreign Ministry Spokesperson Esmaeil Baghaei told ABC News Live.

Earlier Saturday, Israel said it had "eliminated ... several senior officials" in Iran but provided no further details.

Asked about a possible pathway for a peaceful end, Baghaei said "diplomacy was betrayed for the second time during the last nine months."

"We came to these negotiations with all good faith and seriousness," Baghaei told ABC News in the interview.

Baghaei also said talk of Iran's nuclear program was part of a "disinformation campaign" against Iran.

"Iran was not seeking nuclear weapons," Baghaei said.

Baghaei said Iran has been striking other countries in the Gulf because the U.S. is using their territories to launch its attack against Iran.

"This is a war of choice by the American administration," Baghaei said. "We are defending ourselves."

At least 201 people had been killed and 747 others injured across Iran as of Saturday evening local time, a spokesperson for the Iranian Red Crescent Society told Iranian media.

Rescue crews have been active in 24 provinces and relief is actively being provided, the spokesperson further said.