Vice President JD Vance is leading the U.S. delegation in Switzerland.
President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israeli strikes targeting military, government and infrastructure sites.
Following the announcement of a two-week ceasefire, initial U.S.-Iran talks in Pakistan in April failed to reach a peace deal. Trump later announced the open-ended extension of the ceasefire and the continuation of a U.S. blockade until negotiations concluded.
On Sunday, Trump announced that the U.S. and Iran had reached a "great deal." The memorandum of understanding was read to reporters on Wednesday, and the U.S. and Iranian presidents signed it that day, a White House official said.
Vice President JD Vance landed in Lucerne, Switzerland, just before 12 a.m. ET, according to his office.
No official schedule for his visit has been made public yet.
Vance is set to join Special Envoy Steve Witkoff and Jared Kushner in the region for expected talks with Iran.
Vice President JD Vance is en route to Switzerland where talks between the U.S. and Iran are expected to take place.
"I think we're going to hopefully make progress on the nuclear issue, make progress on the Lebanon ceasefire issue," Vance told reporters Saturday.
Vance will join Special Envoy Steve Witkoff and Jared Kushner who are already on the ground in Europe. Vance said Pakistan and Qatar would also be involved in the talks.
"I can only be there for a day or two," Vance told reporters in brief remarks before boarding his flight. "I think we're going to hopefully make progress on the nuclear issue, make progress on the Lebanon ceasefire issue. Those are the two big things that I think we're going to be focused on. I'm sure the Iranians are going to have issues they'd like to discuss as well."
An Israel Defense Forces official said Hezbollah fired over 50 rockets against Israel through Saturday night, targeting soldiers operating in southern Lebanon.
The official accused Hezbollah of continuous and repeated violations of the ceasefire.
Five IDF soldiers were killed in southern Lebanon in the last 48 hours, according to the IDF official.
The IDF is operating in Tebnit, with the official saying it is targeting infrastructure and threats to the IDF.
The official said the IDF received updated directives to ceasefire, saying it is not conducting proactive strikes.
After Iran said the Strait of Hormuz is closed, U.S. Central Command pushed back saying it is in control of the strait.
"Iran does not control the Strait of Hormuz. Traffic continues to flow, and U.S. forces are monitoring the situation to ensure this remains the case," U.S. Central Command spokesman Tim Hawkins said.
