U.S. forces struck 90 Iranian military targets overnight, Central Command said.
President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israeli strikes targeting military, government and infrastructure sites.
Delegations from the U.S. and Iran entered negotiations last month aimed at a war-ending deal based on a memorandum of understanding signed by both countries.
The U.S. and Iran nonetheless exchanged limited strikes in late June despite the signing of the memorandum and amid the continuation of peace talks.
The U.S. latest airstrikes on Iran are bigger in scope than last night's strikes, which hit more than 80 targets, according to a U.S. official.
Tonight's targets include coastal radar sites and anti-ship missile locations, according to the official.
-ABC News' Luis Martinez
U.S. Central Command announced it has begun launching "additional strikes against Iran to further degrade their ability to threaten freedom of navigation in the Strait of Hormuz" on Wednesday.
"The United States is holding Iran accountable for recent unjustified aggression against commercial shipping and civilian crews freely navigating a vital international waterway," CENTCOM said in a statement on X.
Local sources have reported hearing several explosions near Bandar Abbas and Sirik, according to State Media ISNA.
The coastal defenses of Bandar Abbas and Qeshm are confronting hostile target, Iranian state media FARS said Wednesday.
Since the start of the war, Iran has managed to shoot down roughly 30 U.S. MQ-9 Reaper unmanned drones, according to a U.S. official.
Reapers, initially introduced in the Air Force in 2007, can be armed with a various missiles and bombs and is emblematic of the increasing reliance on drone warfare in the Middle East and other war zones.
The drones cost roughly $30 million each.
-ABC News' Steven Beynon
