State Department tells Americans worldwide to 'exercise increased caution'

The war entered its fourth week on Saturday.

Last Updated: March 22, 2026, 8:29 PM EDT

President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israel strikes attack targeting military and government sites, officials said.

Ayatollah Ali Khamenei was among those killed in Tehran on the first day of strikes and his son Mojtaba Khamenei was chosen to succeed him. Iran is responding with missile and drone attacks targeting Israel, regional U.S. bases and multiple Gulf nations. Iran is also attempting to block some shipping traffic through the Strait of Hormuz.

Israel is also intensifying its long-running strike campaign against the Iran-backed Hezbollah militia in Lebanon.

Watch special coverage on Nightline, "War with Iran," each night on ABC and streaming on Disney+ and Hulu.

Mar 21, 2026, 12:02 PM EDT

Iran continues to fire missiles and drones at countries in the region

Iran is continuing to fire missiles and drones at countries in the region, including Kuwait and the United Arab Emirates.

Air defenses in Kuwait intercepted nine ballistic missiles and four drones that entered its airspace over the last 24 hours, the Kuwait Army General Staff Headquarters said in a post on X on Saturday.

The United Arab Emirates Ministry of Defense announced on Saturday air defense systems engaged three ballistic missile and eight drones launched from Iran.

-ABC News' Othon Leyva

Mar 21, 2026, 11:37 AM EDT

22 countries have signed onto joint statement on Strait of Hormuz

Twenty-two countries have now signed onto a joint statement condemning Iran's attacks on shipping vessels in the Gulf and saying they are ready to join "appropriate efforts" to ‌ensure safe passage through the Strait of Hormuz.

Those countries include the United Arab Emirates, the United Kingdom, France, Germany, Italy, the Netherlands, Japan, Canada, Republic of Korea, New Zealand, Denmark, Latvia, Slovenia, Estonia, Norway, Sweden, Finland, Czechia, Romania, Bahrain, Lithuania and Australia.

Tankers sail in the Gulf, near the Strait of Hormuz, as seen from northern Ras al-Khaimah, near the border with Oman's Musandam governance, amid the U.S.-Israeli conflict with Iran, in United Arab Emirates, March 11, 2026.
Reuters

The statement does not outline any specific commitments to ensuring the waterway's safety.

Italy's Minister of Defense Guido Crosetto, referencing the joint statement on X, said there is "no war mission" and there will be "no entry into Hormuz without a truce and without an extended multilateral initiative."

-ABC News' Victoria Beaule

Mar 21, 2026, 9:36 AM EDT

CENTCOM gives update as war enters 4th week: 'Our progress is obvious'

Adm. Brad Cooper, the head of U.S. Central Command, provided an update on Saturday as the U.S. war in Iran entered its fourth week.

Cooper, in a video message, said the U.S. military has struck 8,000 military targets, including 130 Iranian vessels.

"Their Navy is not sailing, their tactical fighters are not flying and they have lost the ability to launch missiles and drones at the high rates seen at the beginning of the conflict," Cooper said. "Our progress is obvious."

Adm. Brad Cooper, the head of U.S. Central Command, is shown in this screen grab from a video released on March 21, 2026.
U.S. Central Command

Addressing Iran's blockade of the Strait of Hormuz, Cooper said the U.S. dropped "multiple 5,000-pound bombs" on an underground weapons storage facility on Iran's coast in an effort to degrade it's military capabilities in the crucial shipping lane.

"My operational assessment continues to be Iran's combat capability is on the steady decline as our offensive strikes ramp up," he said.

Mar 21, 2026, 12:20 PM EDT

Iran says its Natanz nuclear facility was targeted again in US-Israeli attack

Iranian media is reporting that U.S.-Israeli strikes again targeted Iran's Natanz nuclear facility Saturday morning.

No leakage of radioactive materials has been reported in the complex and there is no danger to residents in the surrounding area, according to social media posts by the Iranian judiciary's Mizan News Agency and Iran's semiofficial, IRGC-affiliated Tasnim News Agency.

CENTCOM declined to comment on this or provide details. ABC News has reached out to the Israel Defense Forces.

A satellite image shows a closer view of the Natanz Nuclear Facility with new building damage, amid the U.S.-Israeli conflict with Iran, near Natanz, Iran, March 2, 2026.
Vantor via Reuters

Earlier this month, the International Atomic Energy Agency (IAEA) -- the nuclear watchdog of the United Nations -- confirmed that entrances to Iran's underground and previously bombed uranium-enrichment plant at Natanz had been recently damaged by the U.S.-Israeli strikes on the country.

-ABC News' Morgan Winsor

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