State Department tells Americans worldwide to 'exercise increased caution'

The war entered its fourth week on Saturday.

ByKevin Shalvey, Jon Haworth, Nadine El-Bawab, and Meredith Deliso
Last Updated: March 22, 2026, 8:29 PM EDT

President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israel strikes attack targeting military and government sites, officials said.

Ayatollah Ali Khamenei was among those killed in Tehran on the first day of strikes and his son Mojtaba Khamenei was chosen to succeed him. Iran is responding with missile and drone attacks targeting Israel, regional U.S. bases and multiple Gulf nations. Iran is also attempting to block some shipping traffic through the Strait of Hormuz.

Israel is also intensifying its long-running strike campaign against the Iran-backed Hezbollah militia in Lebanon.

Watch special coverage on Nightline, "War with Iran," each night on ABC and streaming on Disney+ and Hulu.

Key Headlines

Here's how the news is developing.
Mar 22, 2026, 8:58 AM EDT

15 injured in Tel Aviv by Iranian missile attack, officials say

15 people were injured in an Iranian missile attack in the Tel Aviv area Sunday, according to Israel Fire and Rescue.

One of the injured is in moderate condition while the rest suffered mild injuries, emergency services officials said.

According to Israel Fire and Rescue there were several similar scenes across central Israel, including a vehicle that was hit as well as a hit on a building in Tel Aviv. There were also strikes on several locations in surrounding cities, officials said.

-ABC News' Dorit Long and Jordana Miller

Mar 22, 2026, 5:33 AM EDT

Iran warns of retaliatory strikes if US attacks power plants, state media says

The Iranian military said on Sunday that Tehran would seek to retaliate against U.S. energy sites and infrastructure in the Gulf region if Washington moves to strike Iranian power plants, according to Fars News Agency, a semi-official state news agency affiliated with Iran’s Islamic Revolutionary Guard Corps.

This video grab taken from handout footage released by the Iranian Revolutionary Guard Corps (IRGC) on March 12, 2026, shows what it says was the "launch of wave #41 of Iranian missiles."
Iran's Islamic Revolutionary Guard via AFP via Getty Images

Trump said on Saturday that the U.S. would "hit and obliterate" Iranian power plants if the Strait of Hormuz wasn’t opened within 48 hours

"If Iran’s fuel and energy infrastructure is attacked by the enemy, all energy infrastructure, as well as information technology (IT) and water desalination facilities, belonging to the U.S. and the regime in the region will be targeted pursuant to previous warnings," said Lt. Col. Ebrahim Zolfaqari, a spokesperson for the Iranian Armed Forces, according to Fars.

Mar 22, 2026, 4:36 AM EDT

Iran's internet blackout enters 23rd day, monitor says

The near-total internet blackout in Iran entered its 23rd day early on Sunday, according to NetBlocks, a web monitoring organization.

"The measure adds to the wartime distress of millions of civilians who lack independent sources of information and alerts," NetBlocks said.

Mar 22, 2026, 3:37 AM EDT

Shell launched into Israel from Lebanon, IDF says

A shell launched from Lebanon into northern Israel resulted in damage, the Israel Defense Forces said on Sunday.

"The incident is under investigation," an IDF spokesperson said. Israel has been targeting infrastructure related to Hezbollah, an Iranian proxy, in southern Lebanon.

Israel's first responders said two vehicles had caught fire near the border, adding in an update that there appeared to be someone "trapped in a vehicle, showing no signs of life."

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