State Department tells Americans worldwide to 'exercise increased caution'

The war entered its fourth week on Saturday.

Last Updated: March 22, 2026, 8:29 PM EDT

President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israel strikes attack targeting military and government sites, officials said.

Ayatollah Ali Khamenei was among those killed in Tehran on the first day of strikes and his son Mojtaba Khamenei was chosen to succeed him. Iran is responding with missile and drone attacks targeting Israel, regional U.S. bases and multiple Gulf nations. Iran is also attempting to block some shipping traffic through the Strait of Hormuz.

Israel is also intensifying its long-running strike campaign against the Iran-backed Hezbollah militia in Lebanon.

Watch special coverage on Nightline, "War with Iran," each night on ABC and streaming on Disney+ and Hulu.

Mar 22, 2026, 10:24 AM EDT

'Iran endangers the entire world,' Netanyahu says

During a visit Sunday to the site of an Iranian missile strike in Arad, in southern Israel, Israeli Prime Minister Benjamin Netanyahu said the strikes were "proof that Iran endangers the entire world."

“If you want proof that Iran endangers the entire world, the last 48 hours have given it. In the last 48 hours, Iran targeted a civilian area. They're doing that as a mass murder weapon. Luckily, no one was killed, but that's due to luck, not their intention. Their intention is to murder civilians," Netanyahu said.

PHOTO: An infographic titled 'Diego Garcia Base' created in Ankara, Turkey, on March 21, 2026.
An infographic titled 'Diego Garcia Base' created in Ankara, Turkey, on March 21, 2026. The island, the largest in the Chagos Archipelago in the central Indian Ocean, has hosted a joint US-UK military presence since the 1970s and serves as a base for long-range bombers and other strategic assets.
Mehmet Yaren Bozgun/Anadolu via Getty Images

Netanyahu also noted Friday morning's reported launch of two ballistic missiles at a joint U.S.-U.K. military base on the island of Diego Garcia, in the Indian Ocean, some 2,000 miles south of Iran. Neither of the missiles struck the base, nor is it clear how far the missiles traveled.

"I've been warning all the time. They have now the capacity to reach deep into Europe," Netanyahu said, in part. "They are putting everyone in their sights."

"What more proof do you need that this regime that threatens the entire world has to be stopped?" Netanyahu said. "Israel and the United States are working together for the entire world. And it's time to see the leaders of the rest of the countries join up."

-ABC News' Jordana Miller

Mar 22, 2026, 8:58 AM EDT

15 injured in Tel Aviv by Iranian missile attack, officials say

15 people were injured in an Iranian missile attack in the Tel Aviv area Sunday, according to Israel Fire and Rescue.

One of the injured is in moderate condition while the rest suffered mild injuries, emergency services officials said.

According to Israel Fire and Rescue there were several similar scenes across central Israel, including a vehicle that was hit as well as a hit on a building in Tel Aviv. There were also strikes on several locations in surrounding cities, officials said.

-ABC News' Dorit Long and Jordana Miller

Mar 22, 2026, 5:33 AM EDT

Iran warns of retaliatory strikes if US attacks power plants, state media says

The Iranian military said on Sunday that Tehran would seek to retaliate against U.S. energy sites and infrastructure in the Gulf region if Washington moves to strike Iranian power plants, according to Fars News Agency, a semi-official state news agency affiliated with Iran’s Islamic Revolutionary Guard Corps.

This video grab taken from handout footage released by the Iranian Revolutionary Guard Corps (IRGC) on March 12, 2026, shows what it says was the "launch of wave #41 of Iranian missiles."
Iran's Islamic Revolutionary Guard via AFP via Getty Images

Trump said on Saturday that the U.S. would "hit and obliterate" Iranian power plants if the Strait of Hormuz wasn’t opened within 48 hours

"If Iran’s fuel and energy infrastructure is attacked by the enemy, all energy infrastructure, as well as information technology (IT) and water desalination facilities, belonging to the U.S. and the regime in the region will be targeted pursuant to previous warnings," said Lt. Col. Ebrahim Zolfaqari, a spokesperson for the Iranian Armed Forces, according to Fars.

Mar 22, 2026, 4:36 AM EDT

Iran's internet blackout enters 23rd day, monitor says

The near-total internet blackout in Iran entered its 23rd day early on Sunday, according to NetBlocks, a web monitoring organization.

"The measure adds to the wartime distress of millions of civilians who lack independent sources of information and alerts," NetBlocks said.

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