Israel-Iran updates: Iran launches more missiles at Israel, sirens sound in Tel Aviv and Jerusalem

President Donald Trump addressed the possibility of an Israeli strike on Iran against the backdrop of the U.S. pursuing a nuclear deal with Tehran.

"As long as I think there is agreement, I don't want them going in because I think that would blow it," said during an event at the White House. "It might help it actually, but it also could blow it."

Trump continued to characterize past discussions between American and Iranian negotiators as "very good," without saying whether he believed they would ultimately be able to reach an agreement.

The president also acknowledged that "something could happen soon" in the region.

"I don't want to say imminent. But it looks like it's something that could very well happen," Trump told ABC News White House Correspondent Selina Wang when she asked whether an Israeli attack was imminent.

"Look, it's very simple. Not complicated: Iran cannot have a nuclear weapon," he said.

–ABC News’ Shannon Kingston

Sen. Jack Reed, the top Democrat on the Senate Armed Services Committee, called Israel’s strike on Iran a "reckless escalation that risks igniting regional violence."

"While tensions between Israel and Iran are real and complex, military aggression of this scale is never the answer," Reed said in a statement Thursday night.

Reed called on President Donald Trump to be "crystal clear with the American people and the international community in charting a way forward."

"The world cannot afford more devastating conflict born of short-sighted violence," he said.

-ABC News' Allie Pecorin

The IDF said the operation, titled "Rising Lion," comes after intelligence identified that Iran has "significantly advanced towards obtaining a nuclear weapon," alleging this capability would allow them to act against Israel.

Israel estimates Iran now has enough enriched material for several nuclear bombs, the IDF and an Israeli official familiar with the operation told ABC News.

After Israel launched what it called a "preemptive strike" against Iran, Sec. of State Marco Rubio released a statement saying, "Tonight, Israel took unilateral action against Iran. We are not involved in strikes against Iran and our top priority is protecting American forces in the region."

Rubio said the U.S. was advised by Israel that "they believe this action was necessary for its self-defense."

"President Trump and the Administration have taken all necessary steps to protect our forces and remain in close contact with our regional partners. Let me be clear: Iran should not target U.S. interests or personnel,” Rubio's statement continued.