Israel-Iran updates: Iran launches more missiles at Israel, sirens sound in Tel Aviv and Jerusalem

Speaker of the House Mike Johnson issued a warning to Iran on Friday, saying it will face grave consequences if it targets U.S. interests.

"Israel and the United States have been united, including in our shared insistence that Iran must never obtain a nuclear weapon. President Trump and his Administration have worked tirelessly to ensure that outcome. Unfortunately, Iran has refused to agree and even declared yesterday its intent to build a new enrichment facility," Johnson said in a statement.

"Israel decided it needed to take action to defend itself. They were clearly within their right to do so," Johnson said.

-ABC News' Lauren Peller

ABC News' Chief Washington Correspondent Jonathan Karl spoke to President Donald Trump on the phone early Friday morning and asked him about the attack on Iran.

"I think it's been excellent," Trump said. "We gave them a chance and they didn't take it. They got hit hard, very hard. They got hit about as hard as you're going to get hit. And there's more to come. A lot more."

When asked if the United States participated in the attack in any way, Trump responded by saying "I don't want to comment on that."

-ABC News' Chief Washington Correspondent Jonathan Karl

President Donald Trump is urging Iranian officials to strike a nuclear deal with the United States, suggesting the drawn-out negotiations between the two sides are what caused Israel to launch a preemptive strike.

"I gave Iran chance after chance to make a deal. I told them, in the strongest of words, to 'just do it,' but no matter how hard they tried, no matter how close they got, they just couldn’t get it done," Trump claimed in a social media post.

He then issued a stark warning that there will be more destruction if there isn't a deal signed soon.

"There has already been great death and destruction, but there is still time to make this slaughter, with the next already planned attacks being even more brutal, come to an end. Iran must make a deal, before there is nothing left, and save what was once known as the Iranian Empire," he added.

-ABC News' Lalee Ibssa

Iran has confirmed the deaths of the top general of Iran's Revolutionary Guard as well as several top scientists, according to the general staff of the armed forces of the Islamic Republic of Iran.

Hossein Salami, the IRGC commander-in-chief has been confirmed to have been killed along with Gholamali Rashid, deputy chief of the general staff of the armed forces of Iran, Dr. Mohammad Mehdi Tehranchi, physicist and president of Islamic Azad University, and nuclear scientist Dr. Fereydoun Abbasi, Iran said.

Ali Shamkhani, a member of the Expediency Discernment Council of Iran was seriously injured but is still alive, Iran said, and the status of Dr. Abdolhamid Minouchehr, the head of nuclear engineering at Iran's Shahid Beheshti University, is yet to be confirmed.

Meanwhile, Iranian State TV is reporting several residential neighborhoods and apartment complexes were hit and says that there were casualties of civilians and children in the attack, though numbers have yet to be confirmed.