The Gulf Coast is bracing for dangerous conditions, extreme wind and flooding.
Communities on the U.S. Gulf Coast are bracing as Hurricane Isaias made landfall Friday night as a Category 2 storm.
The storm, with winds up to 105 mph, made landfall near Destin, Florida, in the Florida Panhandle at 8:30 p.m. CT. As it continued its march north over the western part of the Panhandle, the storm weakened to a Category 1.
A hurricane warning is currently in effect from just east of Biloxi, Mississippi, through Mobile and Pensacola to Panama City and Mexico Beach, Florida.
Many low-lying and coastal areas, particularly on the Florida Panhandle, are under evacuation orders, with communities preparing for strong winds that could near 120 mph in some locations, Florida Gov. Ron DeSantis said in a press conference Friday morning.
Storm surge warnings are also in place along the coast, with surges forecast to reach up to 9 feet from the Santa Rosa/Okaloosa County Line, Florida, to Grayton Beach, Florida.
At least 800,000 customers in Florida, Alabama and Georgia are currently without power Saturday morning as Hurricane Isaias made landfall near Destin, Florida, in the Florida Panhandle on Friday night.
As of 3:39 a.m. ET on Saturday, at least 445,000 are without power in Florida, with an estimated 309,000 in Alabama and 50,000 in Georgia also without power in the hurricane zone.
-ABC News' Michael O'Keefe
Hurricane Isaias continued its march north over the western Florida Panhandle on Friday night, although it weakened to a Category 1 storm, the National Weather Service said.
Maximum winds were at 90 mph and it was moving at 20 mph, the NWS said.
Florida Gov. Ron DeSantis provided an update on Hurricane Isaias after the storm made landfall in the state Friday night.
DeSantis said wind shear weakened the storm from a Category 3 to a Category 2 before landfall, although strong winds and heavy rainfall remained significant threats.
Florida Department of Transportation crews and search-and-rescue teams were scheduled to begin mobilizing around 3 a.m. Saturday.
Transportation crews planned to clear debris from roadways and inspect bridges, while emergency responders, including the Florida National Guard and Florida Fish and Wildlife Conservation Commission, prepared to assist with rescue operations where needed.
There were approximately 260,000 electric utility accounts without power across the region, he said. Utility crews were prepared to begin restoration work as soon as conditions became safe.
The governor said he would provide another update on Saturday morning.
-ABC News' Jason Volack
Life-threatening storm surge is hitting the Gulf Coast as dangerous hurricane conditions and flash flooding begin to spread inland, the National Weather Service said.
Radar and surface observations indicated that the maximum sustained winds are now 100 mph, NWS said.
